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Miniolins A-C, novel isomeric furanones induced by epigenetic manipulation of Penicillium minioluteum

RSC Advances, ISSN: 2046-2069, Vol: 5, Issue: 3, Page: 2185-2190
2015
  • 22
    Citations
  • 0
    Usage
  • 12
    Captures
  • 1
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    22
    • Citation Indexes
      22
  • Captures
    12
  • Mentions
    1
    • References
      1
      • 1

Article Description

Cultivation of Penicillium minioluteum with azacitidine, a DNA methyltransferase inhibitor, led to the isolation of a novel type of aspertetronin dimer, named miniolins A-C (1-3), along with their precursor aspertetronin A (4). The structures of 1-3 were elucidated by extensive spectroscopic methods, and the absolute configurations were assigned by the chiral HPLC analysis of chemical degradation products and electronic circular dichroism associated with the TDDFT computational method (CAM-B3LYP/TZVP). The miniolins showed moderate cytotoxic activity against Hela cell lines. This journal is

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