Distinct optical and kinetic responses from E/Z isomers of caspase probes with aggregation-induced emission characteristics
Journal of Materials Chemistry B, ISSN: 2050-750X, Vol: 2, Issue: 27, Page: 4363-4370
2014
- 47Citations
- 23Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations47
- Citation Indexes45
- CrossRef45
- 42
- Patent Family Citations2
- Patent Families2
- Captures23
- Readers23
- 23
Article Description
A dual-labeled probe for monitoring caspase activity was designed and synthesized based on a tetraphenylethene (TPE) fluorogen with aggregation-induced emission characteristics and a caspase-specific Asp-Glu-Val-Asp (DEVD) peptide. Two stereoisomers were furnished and successfully separated by HPLC. We demonstrated for the first time the effect of isomerization on the reaction kinetics between the probes and caspase. It was revealed that caspase can produce a much higher light-up ratio for the Z-TPE-2DEVD probe, while its kinetics favor E-TPE-2DEVD due to enhanced probability of optimal binding between the two. Understanding the stereoisomers and their biological functions will open new opportunities for bioprobe design with optimized performance. This journal is © the Partner Organisations 2014.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84902664381&origin=inward; http://dx.doi.org/10.1039/c4tb00405a; http://www.ncbi.nlm.nih.gov/pubmed/32261576; https://xlink.rsc.org/?DOI=C4TB00405A; https://dx.doi.org/10.1039/c4tb00405a; https://pubs.rsc.org/en/content/articlelanding/2014/TB/C4TB00405A
Royal Society of Chemistry (RSC)
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