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Cobalt(II)/silver relay catalytic isocyanide insertion/cycloaddition cascades: A new access to pyrrolo[2,3-b]indoles

Chemical Communications, ISSN: 1364-548X, Vol: 51, Issue: 46, Page: 9519-9522
2015
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Cobalt(II)/silver relay catalytic isocyanide insertion/cycloaddition cascades: a new access to pyrrolo[2,3-b]indoles.

Authors: Qian Gao, Peng Zhou, Feng Liu, Wen-Juan Hao, Changsheng Yao, Bo Jiang, Shu-Jiang Tu PMID: 25967928 DOI: 10.1039/c5cc02754c Publication Type: Research Support, Non-U.S. Gov’t

Article Description

The combination of Co(acac) and AgOTf enables the bimetallic relay catalysis reaction of 2-ethynylanilines and isocyanides, allowing easy and low-cost access to new densely functionalized pyrrolo[2,3-b]indoles. The reaction pathway involves a Co(acac)-catalyzed double isocyanide insertion followed by a silver-enabled 1,3-dipolar cycloaddition. The synthetic utility of these bicycloaddition reactions results in subsequent C-C and C-N bond-forming events to rapidly build up molecular complexity.

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