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Target-triggered cascade recycling amplification for label-free detection of microRNA and molecular logic operations

Chemical Communications, ISSN: 1364-548X, Vol: 52, Issue: 2, Page: 402-405
2016
  • 37
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  • 12
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Article Description

A cascade recycling amplification (CRA) that implements cascade logic circuits with feedback amplification function is developed for label-free chemiluminescence detection of microRNA-122 with an ultrahigh sensitivity of 0.82 fM and excellent specificity, which is applied to construct a series of molecular-scale two-input logic gates by using microRNAs as inputs and CRA products as outputs.

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