Interstitial fluid pressure regulates collective invasion in engineered human breast tumors via Snail, vimentin, and E-cadherin
Integrative Biology (United Kingdom), ISSN: 1757-9708, Vol: 8, Issue: 3, Page: 319-331
2016
- 81Citations
- 104Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations81
- Citation Indexes81
- 81
- CrossRef26
- Captures104
- Readers104
- 104
Article Description
Many solid tumors exhibit elevated interstitial fluid pressure (IFP). This elevated pressure within the core of the tumor results in outward flow of interstitial fluid to the tumor periphery. We previously found that the directionality of IFP gradients modulates collective invasion from the surface of patterned three-dimensional (3D) aggregates of MDA-MB-231 human breast cancer cells. Here, we used this 3D engineered tumor model to investigate the molecular mechanisms underlying IFP-induced changes in invasive phenotype. We found that IFP alters the expression of genes associated with epithelial-mesenchymal transition (EMT). Specifically, the levels of Snail, vimentin, and E-cadherin were increased under pressure conditions that promoted collective invasion. These changes in gene expression were sufficient to direct collective invasion in response to IFP. Furthermore, we found that IFP modulates the motility and persistence of individual cells within the aggregates, which are also influenced by the expression levels of EMT markers. Together, these data provide insight into the molecular mechanisms that guide collective invasion from primary tumors in response to IFP.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84960962968&origin=inward; http://dx.doi.org/10.1039/c5ib00282f; http://www.ncbi.nlm.nih.gov/pubmed/26853861; https://academic.oup.com/ib/article/8/3/319/5181574; http://xlink.rsc.org/?DOI=C5IB00282F; http://pubs.rsc.org/en/content/articlepdf/2016/IB/C5IB00282F; https://dx.doi.org/10.1039/c5ib00282f; http://pubs.rsc.org/en/Content/ArticleLanding/2016/IB/C5IB00282F; https://pubs.rsc.org/en/content/articlepdf/2016/ib/c5ib00282f; https://pubs.rsc.org/en/content/articlelanding/2016/ib/c5ib00282f; https://pubs.rsc.org/en/content/articlehtml/2016/ib/c5ib00282f; https://academic.oup.com/ib/article-pdf/8/3/319/27268791/c5ib00282f.pdf
Oxford University Press (OUP)
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know