Overexpression of div8 increases the production and diversity of divergolides in Streptomyces sp. W112
RSC Advances, ISSN: 2046-2069, Vol: 5, Issue: 119, Page: 98209-98214
2015
- 26Citations
- 1Captures
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Article Description
Isolation and structure elucidation of divergolides from Streptomyces sp. HKI0576 revealed unusual ansamycin diversification reactions and the biosynthetic flexibility of the divergolide family. The production of divergolide E in Streptomyces sp. W112 was previously increased by overexpression of div8, which belongs to ATP-binding regulators of the LuxR family. In this study, we have further characterized the products of the div8-overexpressed mutant and five new divergolide congeners (1-5) were elucidated. Among them, 1-3 features conserved divergolide A skeleton, and 4 and 5 are lactone isomers and seco variant of divergolides E and D, respectively. Divergolides O-S (1-5) showed almost no toxicity to tested human cancer cell lines of MDA-MB-231, PC3 and HeLa at 50 μM. Whereas, 4 and 5 significantly inhibited the secretion of SPI-1 effectors.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84948400108&origin=inward; http://dx.doi.org/10.1039/c5ra20083k; https://xlink.rsc.org/?DOI=C5RA20083K; http://xlink.rsc.org/?DOI=C5RA20083K; http://pubs.rsc.org/en/content/articlepdf/2015/RA/C5RA20083K; https://dx.doi.org/10.1039/c5ra20083k; https://pubs.rsc.org/en/content/articlelanding/2015/ra/c5ra20083k
Royal Society of Chemistry (RSC)
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