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A dual-channel detection of mercuric ions using a label free G-quadruplex-based DNAzyme molecule

Analyst, ISSN: 1364-5528, Vol: 141, Issue: 13, Page: 3997-4000
2016
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Article Description

We have constructed a 'turn-off' and label free bio-sensor using a DNAzyme molecule. This facile bio-sensor is capable of selective detection of mercuric ions with a high sensitivity and satisfactory dynamic range. More importantly, it is able to generate both fluorescent and colourimetric signals for detection. This dual-channel bio-sensor is expected to afford high detection confidence and overcome false-positive readout especially when assaying complex biological samples.

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