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Pd-Catalyzed C(sp)-H carbonylation of 2-benzylpyridines for the synthesis of pyridoisoquinolinones

Chemical Communications, ISSN: 1364-548X, Vol: 52, Issue: 87, Page: 12873-12876
2016
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Article Description

An efficient synthesis of pyridoisoquinolinones, through Pd-catalyzed carbonylative annulation of 2-benzylpyridines, has been developed. The pyridinyl moiety in the substrate acts as both a directing group and an internal nucleophile for sp C-H activation and pyridocarbonylation. The ready availability of 2-benzylpyridines as well as the operational practicality makes this transformation potentially useful for the synthesis of analogues of protoberberine alkaloids.

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