Synthesis, crystal structure, cytotoxicity and action mechanism of Zn(II) and Mn(II) complexes with 4-([2,2′:6′,2′′-terpyridin]-4′-yl)-: N, N -diethylaniline as a ligand
MedChemComm, ISSN: 2040-2511, Vol: 7, Issue: 6, Page: 1132-1137
2016
- 8Citations
- 13Captures
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Article Description
Two metallo-complexes, [Mn(L)]·2ClO (1) and [Zn(L)(NO)] (2), with 4-([2,2′:6′,2′′-terpyridin]-4′-yl)-N,N-diethylaniline (L) as the ligand were synthesized and characterized. They exhibited selective cytotoxicity against BEL-7404, SK-OV-3, MGC80-3, and T-24 cell lines with IC values in the micromolar range (1.28-14.86 μM). Further mechanistic studies showed that complexes 1 and 2 inhibited telomerase by interacting with c-myc G-quadruplex DNA and induced cell cycle arrest at the S phase. They also caused the down-regulation of cdc25 A, cyclin A, cyclin B and CDK2, and the up-regulation of p21, p27 and p53.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84975247387&origin=inward; http://dx.doi.org/10.1039/c6md00098c; http://xlink.rsc.org/?DOI=C6MD00098C; http://pubs.rsc.org/en/content/articlepdf/2016/MD/C6MD00098C; https://xlink.rsc.org/?DOI=C6MD00098C; https://dx.doi.org/10.1039/c6md00098c; https://pubs.rsc.org/en/content/articlelanding/2016/md/c6md00098c
Royal Society of Chemistry (RSC)
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