Gold nanoparticles/Orange II functionalized graphene nanohybrid based electrochemical aptasensor for label-free determination of insulin
RSC Advances, ISSN: 2046-2069, Vol: 6, Issue: 36, Page: 30732-30738
2016
- 30Citations
- 24Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Article Description
Nanocomposites, gold nanoparticles on Orange II functionalized graphene (AuNPs/O-GNs), were developed to modify the electrode surface for anchoring an insulin binding aptamer. The nanocomposites integrate the high electrical conductivity of graphene, and the easily functionalized surface chemistry of AuNPs along with excellent biocompatibility. The characterization using UV-vis absorption spectroscopy, transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy (XPS) revealed the successful synthesis of AuNPs/O-GNs. The determination of insulin by electrochemistry indicated the electrochemical aptamer sensor has good selectivity and high sensitivity at physiological conditions. The linear range was from 1.0 10 to 5.0 10 mol L with a low detection limit of 6.0 10 mol L (S/N ¼ 3). The recovery of insulin in human blood serum samples was from 102.3% to 104.7%. The aptamer sensor provided a promising strategy for insulin detection in clinical diagnostics.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85046800161&origin=inward; http://dx.doi.org/10.1039/c6ra00329j; http://xlink.rsc.org/?DOI=C6RA00329J; http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA00329J; https://xlink.rsc.org/?DOI=C6RA00329J; https://dx.doi.org/10.1039/c6ra00329j; https://pubs.rsc.org/en/content/articlelanding/2016/ra/c6ra00329j
Royal Society of Chemistry (RSC)
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