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“Activography”: a novel, versatile and easily adaptable method for monitoring enzymatic activities in situ

Chemical Communications, ISSN: 1364-548X, Vol: 53, Issue: 22, Page: 3246-3248
2017
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Article Description

We developed activography to map enzymatic activities on tissue sections using activity-based probes. The assay was validated using a new protease-activity probe on skin biopsies to provide proof-of-concept. Activography is more selective and technically easier than the established in situ zymography, thus, adaptable in routine running clinico-chemical laboratories.

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