Stereodivergent synthesis of all the four stereoisomers of antidepressant reboxetine
Organic and Biomolecular Chemistry, ISSN: 1477-0520, Vol: 15, Issue: 25, Page: 5395-5401
2017
- 9Citations
- 7Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations9
- Citation Indexes9
- CrossRef9
- Captures7
- Readers7
Article Description
Chiral amino alcohol-copper(ii) catalysts Cu-L and Cu-ent-L were utilized to promote the diastereoselective nitroaldol reactions of chiral aldehydes (S)-3 or (R)-3 with nitromethane, which respectively led to the preferential formation of certain stereoisomer for nitro diol derivatives 4. Using this catalytic protocol, all the four stereoisomers of the antidepressant reboxetine were divergently prepared. The highest overall yield of this synthetic route reached up to 30.5% from aldehyde (S)-3.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85021641518&origin=inward; http://dx.doi.org/10.1039/c7ob01283g; http://www.ncbi.nlm.nih.gov/pubmed/28621782; http://xlink.rsc.org/?DOI=C7OB01283G; http://pubs.rsc.org/en/content/articlepdf/2017/OB/C7OB01283G; https://xlink.rsc.org/?DOI=C7OB01283G; https://dx.doi.org/10.1039/c7ob01283g; https://pubs.rsc.org/en/content/articlelanding/2017/ob/c7ob01283g
Royal Society of Chemistry (RSC)
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