Modulating the GSH/Trx selectivity of a fluorogenic disulfide-based thiol sensor to reveal diminished GSH levels under ER stress
Chemical Communications, ISSN: 1364-548X, Vol: 54, Issue: 64, Page: 8897-8900
2018
- 17Citations
- 16Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations17
- Citation Indexes17
- 17
- CrossRef16
- Captures16
- Readers16
- 16
Article Description
We synthesized a fluorogenic disulfide-based naphthalimide thiol probe (ER-Naph) with a hydrophilic endoplasmic reticulum (ER)-guiding glibenclamide unit. Its ER targeting ability and high selectivity to GSH over thioredoxin, a potent competitor, were clearly demonstrated, both in solution and in vitro. Finally, a confocal microscopic investigation revealed that GSH levels in the ER were dramatically decreased under thapsigargin, brefeldin A, and tunicamycin-induced ER stress models.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85051273116&origin=inward; http://dx.doi.org/10.1039/c8cc04846k; http://www.ncbi.nlm.nih.gov/pubmed/30043021; https://xlink.rsc.org/?DOI=C8CC04846K; https://dx.doi.org/10.1039/c8cc04846k; https://pubs.rsc.org/en/content/articlelanding/2018/cc/c8cc04846k
Royal Society of Chemistry (RSC)
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