A guide to maximizing the therapeutic potential of protein-polymer conjugates by rational design
Chemical Society Reviews, ISSN: 1460-4744, Vol: 47, Issue: 24, Page: 8998-9014
2018
- 116Citations
- 146Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations116
- Citation Indexes116
- 116
- CrossRef93
- Captures146
- Readers146
- 146
Review Description
Proteins are an important class of therapeutics that have advantages including high target specificity, but challenges to their use include rapid clearance and low physical stability. Conjugation of synthetic polymers is an effective approach to address the drawbacks and enhance other properties such as solubility. In this review, we present various considerations in synthesizing protein-polymer conjugates for therapeutic applications with a focus on the choice of polymer, protein, and conjugation method, as well as characterization and evaluation of the resulting conjugate in order to maximize the therapeutic potential of the protein drug.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85058295663&origin=inward; http://dx.doi.org/10.1039/c8cs00606g; http://www.ncbi.nlm.nih.gov/pubmed/30443654; https://xlink.rsc.org/?DOI=C8CS00606G; https://dx.doi.org/10.1039/c8cs00606g; https://pubs.rsc.org/en/content/articlelanding/2018/cs/c8cs00606g
Royal Society of Chemistry (RSC)
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