Roles of 2-oxoglutarate oxygenases and isopenicillin N synthase in β-lactam biosynthesis
Natural Product Reports, ISSN: 1460-4752, Vol: 35, Issue: 8, Page: 735-756
2018
- 33Citations
- 57Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations33
- Citation Indexes33
- CrossRef33
- 30
- Captures57
- Readers57
- 57
Article Description
Covering: up to 2017 2-Oxoglutarate (2OG) dependent oxygenases and the homologous oxidase isopenicillin N synthase (IPNS) play crucial roles in the biosynthesis of β-lactam ring containing natural products. IPNS catalyses formation of the bicyclic penicillin nucleus from a tripeptide. 2OG oxygenases catalyse reactions that diversify the chemistry of β-lactams formed by both IPNS and non-oxidative enzymes. Reactions catalysed by the 2OG oxygenases of β-lactam biosynthesis not only involve their typical hydroxylation reactions, but also desaturation, epimerisation, rearrangement, and ring-forming reactions. Some of the enzymes involved in β-lactam biosynthesis exhibit remarkable substrate and product selectivities. We review the roles of 2OG oxygenases and IPNS in β-lactam biosynthesis, highlighting opportunities for application of knowledge of their roles, structures, and mechanisms.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85051757313&origin=inward; http://dx.doi.org/10.1039/c8np00002f; http://www.ncbi.nlm.nih.gov/pubmed/29808887; https://xlink.rsc.org/?DOI=C8NP00002F; https://dx.doi.org/10.1039/c8np00002f; https://pubs.rsc.org/en/content/articlelanding/2018/NP/C8NP00002F
Royal Society of Chemistry (RSC)
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