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Metal-free oxidative coupling of quinoxalin-2(1: H)-ones with arylaldehydes leading to 3-acylated quinoxalin-2(1 H)-ones

Organic and Biomolecular Chemistry, ISSN: 1477-0520, Vol: 16, Issue: 17, Page: 3203-3212
2018
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A facile TBHP-mediated direct oxidative coupling of quinoxalin-2(1H)-ones with arylaldehydes has been developed under metal-free conditions. This method provided a convenient and efficient approach to various 3-acylated quinoxalin-2(1H)-ones from readily available starting materials with excellent regioselectivity. This reaction proceeded efficiently under mild conditions over a broad range of substrates and with functional group tolerance.

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