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The theranostic nanoagent MoC for multi-modal imaging-guided cancer synergistic phototherapy

Biomaterials Science, ISSN: 2047-4849, Vol: 7, Issue: 7, Page: 2729-2739
2019
  • 58
    Citations
  • 0
    Usage
  • 38
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    58
    • Citation Indexes
      58
  • Captures
    38

Article Description

Multifunctional theranostic platforms, especially single component-based platforms, enable both cancer treatment and real-time imaging as well as enhance the efficiency of treatment. In this study, 50 nm MoC nanospheres were explored as a "one-for-all" theranostic agent. The light-harvesting of MoC covered the entire near infrared region, and NIR irradiation concurrently triggered hyperthermia and reactive oxygen species (ROS) production; thus, synergistic outcomes of photothermal and photodynamic therapy could be realized. Both in vitro and in vivo experiments have confirmed the superiority of the synergistic phototherapy in killing cancer cells and removing solid tumors; moreover, MoC proposed herein has been proven to be applicable as a photoacoustic imaging and CT imaging contrast agent for in vivo tumor depiction; furthermore, MoC demonstrates excellent biocompatibility, showing minimal hematotoxicity and tissue toxicity. A theoretical simulation performed by density functional theory revealed that the metallic character and the interband/intraband transition of MoC accounted for its broad photoabsorption. The antitumor mechanism of MoC was investigated on a solid tumor by B-mode ultrasonography (US) and magnetic resonance imaging (MRI), revealing a typical liquefactive necrosis process; hence, herein, the dual-imaging guided phototherapy was efficiently mediated by MoC.

Bibliographic Details

Zhang, Qun; Huang, Weicheng; Yang, Chunyu; Wang, Fei; Song, Chuanqi; Gao, Yan; Qiu, Yunfeng; Yan, Mei; Yang, Bin; Guo, Chongshen

Royal Society of Chemistry (RSC)

Engineering; Materials Science

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