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A Golgi-Targeted off-on fluorescent probe for real-Time monitoring of pH changes: In vivo

Chemical Communications, ISSN: 1364-548X, Vol: 55, Issue: 47, Page: 6685-6688
2019
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Article Description

We present the first Golgi-Targeted small-molecular pH-sensitive fluorescent probe RSG, which allows an off-on fluorescence response to Golgi acidification with high sensitivity and specificity. RSG has been successfully used for real-Time monitoring of Golgi pH changes induced by drug treatment at the cellular level, as well as by the LPS-mediated inflammation in vivo.

Bibliographic Details

Fan, Li; Wang, Xiaodong; Ge, Jinyin; Li, Feng; Zhang, Caihong; Lin, Bo; Shuang, Shaomin; Dong, Chuan

Royal Society of Chemistry (RSC)

Chemical Engineering; Materials Science; Chemistry

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