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Assembly of branched ubiquitin oligomers by click chemistry

Chemical Communications, ISSN: 1364-548X, Vol: 55, Issue: 87, Page: 13093-13095
2019
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Article Description

Ubiquitin monomers functionalized with an azide or multiple alkynes were utilized for the assembly of branched ubiquitin oligomers (K6/K11, K11/K48, K11/K63, K6/K11/K48) by click chemistry. The oligomers resist deubiquitylase-catalysed hydrolysis and exhibit stability in eukaryotic cell lysates.

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