Discovery of (aza)indole derivatives as novel respiratory syncytial virus fusion inhibitors
MedChemComm, ISSN: 2040-2511, Vol: 10, Issue: 6, Page: 970-973
2019
- 4Citations
- 4Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Article Description
A new class of indole derivatives (3) have been identified as potent RSV fusion inhibitors. SAR exploration revealed that 5-Cl and the sulfonyl side chain of the indole scaffold are crucial for anti-RSV activity. Further optimization led to the discovery of a cyclic sulfone (8i) with 2 nM anti-RSV activity and a much improved PK profile compared to the non-cyclic sulfone counterpart.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85067630730&origin=inward; http://dx.doi.org/10.1039/c9md00178f; http://www.ncbi.nlm.nih.gov/pubmed/31303995; https://xlink.rsc.org/?DOI=C9MD00178F; https://dx.doi.org/10.1039/c9md00178f; https://pubs.rsc.org/en/content/articlelanding/2019/md/c9md00178f
Royal Society of Chemistry (RSC)
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