A [bmim]Cl-promoted domino protocol using an isocyanide-based [4+1]-cycloaddition reaction for the synthesis of diversely functionalized 3-Alkylamino-2-Alkyl/aryl/hetero-Aryl indolizine-1-carbonitriles under solvent-free conditions
New Journal of Chemistry, ISSN: 1369-9261, Vol: 44, Issue: 8, Page: 3241-3248
2020
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- 2Captures
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Article Description
A domino protocol involving aldehydes, isocyanides and 2-pyridylacetonitrile in the presence of [bmim]Cl as a promoter and solvent for the synthesis of 3-Alkylamino-2-Alkyl/arylindolizine-1-carbonitriles is described. A wide range of alkyl, aryl and hetero-Aryl aldehydes reacted with 2-pyridylacetonitrile and isocyanides, leading to indolizine derivatives with high selectivity, high atom economy, and good to excellent yields. This straight-forward and highly efficient method allows the synthesis of bis-indolizine-1-carbonitrile derivatives.
Bibliographic Details
Royal Society of Chemistry (RSC)
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