Construction of CPs@MnO-AgNPs as a multifunctional nanosensor for glutathione sensing and cancer theranostics
Nanoscale, ISSN: 2040-3372, Vol: 11, Issue: 40, Page: 18845-18853
2019
- 36Citations
- 24Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations36
- Citation Indexes36
- 36
- CrossRef35
- Captures24
- Readers24
- 24
Article Description
A multifunctional nanosensor of CPs@MnO-AgNPs was constructed for sensitive and selective sensing of GSH and cancer theranostics in this work. The CPs@MnO nanocomposite was synthesized by capping MnO onto carbon nanoparticles through an in situ redox reaction under ultrasonication. AgNPs with fluorescence were obtained through a silver-mirror-like reaction using BSA as both a template and reductant and further anchored onto the surface of CPs@MnO through electrostatic interaction to construct the CPs@MnO-AgNP nanocomposite. The fluorescence of AgNPs was effectively quenched by MnO through an inner filter effect and a static quenching effect and further recovered by GSH owing to the unique redox reaction between GSH and MnO. Therefore, a novel fluorescent turn-on nanosensor was established for GSH sensing in vitro and in vivo. For GSH sensing, a satisfactory linear range of 0.8-80 μM with a detection limit of 0.55 μM was obtained under optimal conditions. Moreover, by integrating the GSH-responsive fluorescence imaging capacity, the photothermal activity of carbon nanoparticles and the anticancer effect of AgNPs, the CPs@MnO-AgNP nanocomposite was successfully applied for cancer theranostics. The fluorescence recognition of cancer was achieved by overexpressing GSH in cancer, meanwhile the photothermal therapy from CPs and chemotherapy from AgNPs jointly produced an enhanced therapeutic effect. This redox-responsive nanocomposite of CPs@MnO-AgNPs improves the MnO nanomaterial-based applications in GSH sensing and cancer theranostics.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85073482201&origin=inward; http://dx.doi.org/10.1039/c9nr06443e; http://www.ncbi.nlm.nih.gov/pubmed/31595915; https://xlink.rsc.org/?DOI=C9NR06443E; https://dx.doi.org/10.1039/c9nr06443e; https://pubs.rsc.org/en/content/articlelanding/2019/nr/c9nr06443e
Royal Society of Chemistry (RSC)
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know