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A rhodium-catalysed three-component reaction to access C1-substituted tetrahydroisoquinolines

Organic and Biomolecular Chemistry, ISSN: 1477-0520, Vol: 17, Issue: 46, Page: 9844-9848
2019
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Article Description

A rhodium-catalyzed three-component reaction of diazo compounds, anilines and C,N-cyclic azomethine imines via trapping of transient ammonium ylides was developed. This reaction provided a simple and convenient approach for the synthesis of pharmaceutically intriguing tetrahydroisoquinoline derivatives in moderate to good yields (36-85%) with good diastereoselectivities (up to 95 : 5 dr) under mild reaction conditions.

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