Rapid route design of AZD7594
Reaction Chemistry and Engineering, ISSN: 2058-9883, Vol: 4, Issue: 9, Page: 1658-1673
2019
- 15Citations
- 28Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Article Description
A wide variety of technology platforms were used to rapidly select a commercial manufacturing route to the inhaled glucocorticoid receptor modulator AZD7594. This collaborative approach to the route design employed idea generation, high-throughput salt formation, solubility and chemical reaction screening, process analytical techniques and factorial experimental design to propose, assess and select the new strategic route within a five-month window. The selected route is currently undergoing further process development and optimisation and will be implemented in future manufacturing campaigns to supply drug substance for ongoing clinical studies and ultimately for the commercially marketed product.
Bibliographic Details
Royal Society of Chemistry (RSC)
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know