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Colchicine selective interaction with oncogene: RET G-quadruplex revealed by NMR

Chemical Communications, ISSN: 1364-548X, Vol: 56, Issue: 14, Page: 2099-2102
2020
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Article Description

G-quadruplexes (G4s) are frequently formed in the promoter regions of oncogenes, considered as promising drug targets for anticancer therapy. Due to high structure similarity of G4s, discovering ligands selectively interacting with only one G4 is extremely difficult. Here, mainly by NMR, we report that colchicine selectively binds to oncogene RET G4-DNA.

Bibliographic Details

Wang, Fei; Wang, Chunxi; Liu, Yaping; Lan, Wenxian; Han, Hao; Wang, Renxiao; Huang, Shaohua; Cao, Chunyang

Royal Society of Chemistry (RSC)

Materials Science; Chemical Engineering; Chemistry

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