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Palladium-catalyzed remote C-H functionalization of 2-aminopyrimidines

Chemical Communications, ISSN: 1364-548X, Vol: 56, Issue: 31, Page: 4284-4287
2020
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Article Description

A straightforward strategy was developed for the arylation and olefination at the C5-position of the N-(alkyl)pyrimidin-2-amine core with readily available aryl halides and alkenes, respectively. This approach was highly regioselective, and the transformation was achieved based on two different (Pd(ii)/Pd(iv)) and (Pd(0)/Pd(ii)) catalytic cycles.

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