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A matrix metalloproteinase activation probe for painting human tumours

Chemical Communications, ISSN: 1364-548X, Vol: 56, Issue: 69, Page: 9962-9965
2020
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Article Description

A probe that allows specific 'painting' of human tumours is described. Probe activation was mediated by specific matrix metalloproteinases, resulting not only in disruption of a FRET pair, but in the generation of a fragment that "fluorescently paints"human tumours. This probe demonstrated rapid and effective human tumour labelling with the potential to allow margin detection during surgical resection.

Bibliographic Details

Mills, Bethany; Norberg, Dominic; Dhaliwal, Kevin; Akram, Ahsan R; Bradley, Mark; Megia-Fernandez, Alicia

Royal Society of Chemistry (RSC)

Chemical Engineering; Materials Science; Chemistry

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