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Anin situsynthesis of silver nanoparticle-loaded genetically engineered polypeptide nanogels for antibacterial and wound healing applications

Dalton Transactions, ISSN: 1477-9234, Vol: 49, Issue: 34, Page: 12049-12055
2020
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The fact that the wounds infected by bacteria are difficult to heal is a major health issue. Herein, we synthesized silver nanoparticle-loaded polypeptide nanogelsviaanin situmethod using UV irradiation, which is a relatively green and simple method. The size of the nanogel and silver nanoparticles could be regulated by changing the concentrations of the polypeptide and silver ions, respectively. Because the polypeptide PCARGD was histidine-rich and biodegradable, the as-synthesized silver nanogels exhibited low toxicity and good biocompatibility. Thein vitroantibacterial experiments showed that the silver nanogels presented excellent antibacterial activity against both Gram-negative and Gram-positive bacteria. Moreover, silver nanogels had a good effect as an antibacterial and wound healing agentin vivo. These findings provide a new strategy and theoretical basis for the synthesis and application of silver nanoparticles.

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