Construction of polysiloxane-based fluorescent probe for visualizing pH down-regulation
Journal of Materials Chemistry C, ISSN: 2050-7526, Vol: 9, Issue: 7, Page: 2392-2397
2021
- 7Citations
- 2Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Article Description
Changes in the intracellular pH values constitute a significant physiological and pathological process and play vital roles in autophagy, self-repairing, and programmed cell apoptosis. A unique fluorescent probe (PN-1) based on polysiloxanes designed using the intramolecular charge transfer (ICT) mechanism has been developed for the detection of the pH down-regulation process for the first time.PN-1has been successfully applied to HeLa cells and HepG2 cells for visualizing the pH value changes in a ratiometric manner. The result presented that, in the normal intracellular autophagy process,PN-1displayed strong blue fluorescence while starvation induced apparent red fluorescence ofPN-1. In addition, the inhibitory effect of chloroquine (CQ) to pH value changes during the cell starvation treatment process has been analyzed. The work indicated that a polysiloxane-based fluorescent probe could be applied to detect pH value changes during autophagy, and paved a new avenue for the further design of fluorescent probes for monitoring pH changes.
Bibliographic Details
Royal Society of Chemistry (RSC)
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know