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Direct asymmetric reductive amination of α-keto acetals: A platform for synthesizing diverse α-functionalized amines

Chemical Communications, ISSN: 1364-548X, Vol: 58, Issue: 4, Page: 513-516
2022
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Article Description

We report an efficient and straightforward method to synthesize enantio-enriched N-unprotected α-amino acetals via ruthenium-catalyzed direct asymmetric reductive amination. The α-amino acetal products are versatile and valuable platform molecules that can be converted to the corresponding α-amino acids, amino alcohols, and other derivatives by convenient transformations.

Bibliographic Details

Shi, Yongjie; Wang, Jingxin; Yang, Feifan; Wang, Chenhan; Zhang, Xumu; Chiu, Pauline; Yin, Qin

Royal Society of Chemistry (RSC)

Materials Science; Chemical Engineering; Chemistry

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