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Phthalimide-based-SSCFreagent for enantioselective dithiotrifluoromethylation

Organic Chemistry Frontiers, ISSN: 2052-4129, Vol: 8, Issue: 6, Page: 1275-1279
2021
  • 31
    Citations
  • 0
    Usage
  • 9
    Captures
  • 0
    Mentions
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Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    31
    • Citation Indexes
      31
  • Captures
    9

Article Description

An electrophilic phthalimide-based-SSCF3 reagent was designed and prepared for straightforward SSCF3 incorporation of diverse β-keto esters in natural products, pharmaceuticals and biological molecules. The asymmetric dithiotrifluoromethylation was achieved with a good to excellent enantioselectivity, catalyzed by a cinchona-alkaloid-based catalyst (DHQD)2PHAL via an ammonium-hydrogen-bonded induction mode. This journal is

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