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Expedient cobalt-catalyzed stereospecific cascade C-N and C-O bond formation of styrene oxides with hydrazones

Chemical Communications, ISSN: 1364-548X, Vol: 58, Issue: 50, Page: 7090-7093
2022
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Cobalt-catalyzed cascade C-N and C-O bond formation of epoxides with hydrazones is described to furnish oxadiazines using air as an oxidant. The catalyst plays a dual role as a Lewis acid followed by a redox catalyst to accomplish the C-H/O-H cyclization. Optically active styrene oxide can be reacted enantiospecifically (>99% ee).

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