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Selective photodynamic eradication of senescent cells with a β-galactosidase-activated photosensitiser

Chemical Communications, ISSN: 1364-548X, Vol: 59, Issue: 23, Page: 3471-3474
2023
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Article Description

A β-galactosidase-responsive photosensitiser has been designed and synthesised. It contains a galactosyl substrate, a boron dipyrromethene-based photosensitising unit and a black hole quencher 2 connected via an AB-type self-immolative linker. This novel photosensitiser can be selectively activated by the senescence-associated β-galactosidase in senescent cells, leading to restoration in fluorescence emission and effective killing of the cells via photodynamic action.

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