Novel electrochemically-mediated peptide dethiylation in processes relevant to native chemical ligation
Organic and Biomolecular Chemistry, ISSN: 1477-0520, Vol: 20, Issue: 36, Page: 7343-7350
2022
- 8Citations
- 11Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Article Description
Here we explore electrochemical dethiylation in processes relevant to Native Chemical Ligation (NCL). NCL's reliance on the redox active amino acid cysteine and β-mercaptamine derivatives suggests a potential role for electrochemistry. We show that the application of a 1 V potential to platinum electrodes in 0.15 M TCEP solution is sufficient to convert Cys to Ala in cyclic peptides, and to cleave the 2-mercapto-2-phenethyl class of acyl transfer auxiliary.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85138458002&origin=inward; http://dx.doi.org/10.1039/d2ob01499h; http://www.ncbi.nlm.nih.gov/pubmed/36073340; https://xlink.rsc.org/?DOI=D2OB01499H; https://dx.doi.org/10.1039/d2ob01499h; https://pubs.rsc.org/en/content/articlelanding/2022/ob/d2ob01499h
Royal Society of Chemistry (RSC)
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