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Improvement in the healing of bone fractures using a cyclodextrin/Ni-MOF nanofibers network: the development of a novel substrate to increase the surface area with desirable functional properties

RSC Advances, ISSN: 2046-2069, Vol: 13, Issue: 9, Page: 5600-5608
2023
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Report Summarizes Bone Fractures Study Findings from Nantong University (Improvement In the Healing of Bone Fractures Using a Cyclodextrin/ni-mof Nanofibers Network: the Development of a Novel Substrate To Increase the Surface Area With ...)

2023 APR 04 (NewsRx) -- By a News Reporter-Staff News Editor at Biotech News Daily -- Researchers detail new data in Bone Diseases and Conditions

Article Description

In this study, a β-cyclodextrins (β-CDs)/Ni-based MOF (β-CDs/Ni-based MOF) fibrous network with focus on biocompatible and biodegradable properties was used as a new material for orthopedic applications. The final products were synthesized by an efficient, rapid, and controllable electrospinning route under optimal conditions, including a flow rate of 0.3 mL g, applied voltage of 18 kV, and spinning distance of 20 cm. Efficient characterization by various analyzes showed that the β-CDs/Ni-based MOF fibrous nanostructures had a thermal stability at about 320 °C and homogeneous particles with a narrow size distribution. The BET analysis results showed a specific surface area of 2140 m g for these compounds, which facilized potential conditions needed for the application of these compounds as a new substrate to improve the healing of bone fractures. The results showed the better porosity of the β-CDs/Ni-based MOF scaffolds as an essential property, leading to higher proliferation and nutrition and oxygen delivery, resulting in more tissue regeneration. This study proposes a novel strategy for a fibrous network substrate with distinct properties for orthopedic purposes.

Bibliographic Details

Lin, Junfei; Zong, Chenyu; Chen, Baisen; Wang, Teng; Xu, Jiacheng; Du, Jiashang; Lin, Yinghao; Gu, Yuming; Zhu, Jianwei

Royal Society of Chemistry (RSC)

Chemistry; Chemical Engineering

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