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Functionalization of arylacetic acids via directing-group-assisted remote meta-C-H activation

Chemical Communications, ISSN: 1364-548X, Vol: 59, Issue: 46, Page: 7084-7087
2023
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Article Description

Herein, we report the first microwave-assisted remote-C-H functionalization aided by a simple nitrile directing template. Notably, the present protocol showed a broad substrate scope via enabling meta-C-H arylation, acetoxylation, and cyanation. Significantly, the microwave-accelerated meta-C-H functionalization was effective with short reaction times without compromising yields and site selectivity. In addition, ibuprofen drug diversification was accomplished by carrying out arylation, acetoxylation, and cyanation. Importantly, meta-dual-hetero functionalization has been presented.

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