A model for N-to-C direction in prebiotic peptide synthesis
Chemical Communications, ISSN: 1364-548X, Vol: 60, Issue: 20, Page: 2748-2751
2024
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Most Recent News
Researchers from Ningbo University Report New Studies and Findings in the Area of Chemicals and Chemistry (A Model for N-to-c Direction In Prebiotic Peptide Synthesis)
2024 MAR 20 (NewsRx) -- By a News Reporter-Staff News Editor at Chemicals & Chemistry Daily Daily -- A new study on Chemicals and Chemistry
Article Description
Drawing inspiration from the initiating amino acid modification in biosynthetic peptides, we have successfully demonstrated a biomimetic mechanism for N-to-C terminal extension in prebiotic peptide synthesis. This achievement was accomplished by using acetylated amino acid amides as the N-terminal substrate for peptide synthesis and amino acid amides as the C-terminal extension, with the reaction carried out in a dry-wet cycle at 80 °C without requiring any activators. This provides a plausible pathway for the formation of prebiotic peptides.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85185471912&origin=inward; http://dx.doi.org/10.1039/d3cc06101a; http://www.ncbi.nlm.nih.gov/pubmed/38362617; https://xlink.rsc.org/?DOI=D3CC06101A; https://dx.doi.org/10.1039/d3cc06101a; https://pubs.rsc.org/en/content/articlelanding/2024/cc/d3cc06101a
Royal Society of Chemistry (RSC)
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