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Enhancement of cell membrane permeability by using charged nanoparticles and a weak external electric field

Physical Chemistry Chemical Physics, ISSN: 1463-9076, Vol: 25, Issue: 47, Page: 32356-32363
2023
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Most Recent News

Department of Chemical Engineering Reports Findings in Nanoparticles (Enhancement of cell membrane permeability by using charged nanoparticles and a weak external electric field)

2023 NOV 01 (NewsRx) -- By a News Reporter-Staff News Editor at Japan Daily Report -- New research on Nanotechnology - Nanoparticles is the subject

Article Description

Because the cell membrane is the main barrier of intracellular delivery, it is important to facilitate and control the translocation of extracellular compounds across it. Our earlier molecular dynamics simulations suggested that charged nanoparticles under a weak external electric field can enhance the permeability of the cell membrane without disrupting it. However, this membrane permeabilization approach has not been tested experimentally. This study investigated the membrane crossing of a model compound (dextran with a M of 3000-5000) using charged nanoparticles and a weak external electric field. A model bilayer lipid membrane was prepared by using a droplet contact method. The permeability of the membrane was evaluated using the electrophysiological technique. Even when the applied electric field was below the critical strength for membrane breakdown, dextran was able to cross the membrane without causing membrane breakdown. These results indicate that adding nanomaterials under a weak electric field may enhance the translocation of delivery compounds across the cell membrane with less damage, suggesting a new strategy for intracellular delivery systems.

Bibliographic Details

Nakamura, Hideya; Okamura, Takumi; Tajima, Masaya; Kawano, Ryuji; Yamaji, Misa; Ohsaki, Shuji; Watano, Satoru

Royal Society of Chemistry (RSC)

Physics and Astronomy; Chemistry

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