Protective effect and mechanism of Lycium ruthenicum polyphenols against acrylamide-induced neurotoxicity
Food and Function, ISSN: 2042-650X, Vol: 14, Issue: 10, Page: 4552-4568
2023
- 6Citations
- 2Captures
- 1Mentions
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Metrics Details
- Citations6
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- CrossRef3
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- Readers2
- Mentions1
- News Mentions1
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Most Recent News
School of Public Health and Management Reports Findings in Life Science (Protective effect and mechanism of Lycium ruthenicum polyphenols against acrylamide-induced neurotoxicity)
2023 APR 19 (NewsRx) -- By a News Reporter-Staff News Editor at Chemicals & Chemistry Daily Daily -- New research on Life Science is the
Article Description
This study aimed to investigate the potential neuroprotective effects of Lycium ruthenicum polyphenols (LRP) against acrylamide (ACR)-induced neurotoxicity and the mechanism of action in vitro and in vivo. LRP treatment significantly attenuated ACR-induced cytotoxicity in SH-SY5Y cells in a dose-dependent manner. LRP treatment increased the nuclear factor erythroid-2-related factor 2 (Nrf2) protein and subsequent activation of downstream proteins in SH-SY5Y cells. LRP treatment down-regulated the expression of relevant apoptotic proteins, including JNK, P-JNK, P38, P-P38, and caspase 3 in ACR-induced cells. In vivo, LRP improved exploratory and locomotor deficits in ACR-induced rats. LRP activated the Nrf2 pathway in the striatum and substantia nigra. LRP treatment attenuated striatal ROS levels and increased GSH and SOD in ACR-induced rats. Immunohistochemistry, western blot, and ELISA revealed a significant increase in tyrosine hydroxylase (TH) neurons and dopamine and its metabolites in the striatum and substantia nigra under the protective effect of LRP. Therefore, LRP can be a protective agent against ACR-induced brain damage.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85152115579&origin=inward; http://dx.doi.org/10.1039/d3fo00623a; http://www.ncbi.nlm.nih.gov/pubmed/37021634; https://xlink.rsc.org/?DOI=D3FO00623A; https://dx.doi.org/10.1039/d3fo00623a; https://pubs.rsc.org/en/content/articlelanding/2023/fo/d3fo00623a
Royal Society of Chemistry (RSC)
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