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Electrodeposition of PEDOT:ClO on non-noble tungsten microwire for nerve and brain recordings

Materials Advances, ISSN: 2633-5409, Vol: 4, Issue: 24, Page: 6741-6753
2023
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Article Description

Tungsten microwires are commonly used in neuroscience for their high mechanical strength, flexibility, which allows tailoring them to brain and peripheral nerve implantations, and cost-effectiveness compared to other electrode materials. However, challenges such as high impedance and foreign body reactions limit their use as acute and chronic electrophysiology tools. In this work, we propose a novel method for successfully coating tungsten microwires with PEDOT (poly(3,4-ethylenedioxythiophene)) doped with perchlorate anions ClO using electropolymerization. Pre-treatment of the microwires with annealing resulted in the formation of a WO coating that facilitated the nucleation and deposition of PEDOT, which was more homogeneous than that on gold microwires under the same conditions. In vitro, PEDOT decreased the impedance and increased the capacitance compared to bare tungsten microwires. In vivo, the PEDOT coating enhanced the signal-to-noise ratio and reduced the standard deviation of noise in acute preliminary electrophysiology recordings of spontaneous activity in the brain and evoked activity in the sciatic nerve of the rat.

Bibliographic Details

Amparo Güemes; Antonio Dominguez-Alfaro; Ryo Mizuta; Santiago Velasco-Bosom; Alejandro Carnicer-Lombarte; George Malliaras; David Mecerreyes; Damiano G. Barone

Royal Society of Chemistry (RSC)

Chemistry; Materials Science

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