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Organic photoredox-catalyzed oxidative azolation of unactivated fluoroarenes

Organic and Biomolecular Chemistry, ISSN: 1477-0520, Vol: 21, Issue: 32, Page: 6503-6508
2023
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Inexpensive and commercially available 2,4,6-triphenylpyrrolium tetrafluoroborate (TPT) is used as an organic photocatalyst for the nucleophilic aromatic substitution of unactivated fluoroarenes with pyrazole derivatives (SAr) to form azole arenes. The use of organic photoredox catalysis enables the easy operation of this method under mild conditions. Various fluorinated aromatic compounds are suitable electrophiles for this transformation.

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