Enantioselective synthesis of chiral BCPs
Organic Chemistry Frontiers, ISSN: 2052-4129, Vol: 11, Issue: 3, Page: 916-928
2023
- 4Citations
- 2Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations4
- Citation Indexes4
- Captures2
- Readers2
Review Description
Bicyclo[1.1.1]pentanes (BCPs) have emerged as an interesting scaffold in drug design. These strained molecules can act as bioisosteres of para-substituted phenyl rings, tert-butyl groups or internal alkynes, leading to drug analogues with enhanced pharmacokinetic and physicochemical properties. Thus, catalytic methodologies for the synthesis of BCPs represent a major goal in modern organic synthesis. In particular, asymmetric transformations that provide chiral BCPs bearing an adjacent stereocenter are particularly valuable to expand the chemical space of this important scaffold. In this article, we discuss the available methodologies for the asymmetric synthesis of α-chiral BCPs, their key mechanistic features and their application in bioisosteric replacements in drug design.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85181804934&origin=inward; http://dx.doi.org/10.1039/d3qo01631e; http://www.ncbi.nlm.nih.gov/pubmed/38298565; https://xlink.rsc.org/?DOI=D3QO01631E; https://dx.doi.org/10.1039/d3qo01631e; https://pubs.rsc.org/en/content/articlelanding/2024/qo/d3qo01631e
Royal Society of Chemistry (RSC)
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