Light-assisted green and efficient construction of thiadiazole/selenadiazole derivatives

Thiadiazole and selenadiazole derivatives are significant organic backbones widely utilized in drugs, bioactive molecules, and functional materials. A green and efficient one-pot synthetic methodology has been developed for the fabrication of thiadiazole/selenadiazole derivatives, which involves photocatalytic induced iodine substitution, oxydic aldehyde formation, and nucleophilic addition, resulting in C-S bond formation and hydrazylation, cyclization, and rearrangement, as well as dehydration. The present method includes good functional group tolerance, simple, mild, metal-free, and safe conditions that are in line with the principles of green chemistry, making this protocol an attractive strategy for the synthesis of bioactive molecules with thiadiazole/selenadiazole frameworks. Gratifyingly, the complanate and conjugate structures of the synthesized compounds ensured attractive fluorescent properties for successful application in biological cell imaging.