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A method for estimation of plasma protein binding using diffusion ordered NMR spectroscopy (DOSY)

RSC Medicinal Chemistry, ISSN: 2632-8682, Vol: 15, Issue: 7, Page: 2372-2379
2024
  • 1
    Citations
  • 0
    Usage
  • 2
    Captures
  • 1
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    1
  • Captures
    2
  • Mentions
    1
    • News Mentions
      1
      • News
        1

Most Recent News

New Medicinal Chemistry Findings from University of Bradford Discussed [A Method for Estimation of Plasma Protein Binding Using Diffusion Ordered Nmr Spectroscopy (Dosy)]

2024 JUL 16 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Daily -- Current study results on Health and Medicine -

Article Description

The plasma protein binding (PPB) of a drug plays a key role in both its pharmacokinetic and pharmacodynamic properties. During lead optimisation, medium and high throughput methods for the early determination of PPB can provide important information about potential PKPD profile within a chemotype or between different chemotype series. Diffusion ordered spectroscopy (DOSY) is an NMR spectroscopic technique that measures the diffusion of a molecule through the magnetic field gradient, according to its molecular size/weight. Here, we describe the use of DOSY for a rapid and straightforward method to evaluate the PPB of drug molecules, using their binding to bovine serum albumin (BSA) as a model.

Bibliographic Details

Taylor, Rachel; Swift, Thomas; Wilkinson, David; Afarinkia, Kamyar

Royal Society of Chemistry (RSC)

Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics; Chemistry

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