PlumX Metrics
Embed PlumX Metrics

Design, synthesis and antiviral evaluation of triazole-linked 7-hydroxycoumarin-monoterpene conjugates as inhibitors of RSV replication

RSC Medicinal Chemistry, ISSN: 2632-8682
2024
  • 0
    Citations
  • 0
    Usage
  • 0
    Captures
  • 1
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Mentions
    1
    • News Mentions
      1
      • 1

Most Recent News

Investigators from N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry Zero in on Respiratory Syncytial Viruses (Design, Synthesis and Antiviral Evaluation of Triazole-linked 7-hydroxycoumarin-monoterpene Conjugates As Inhibitors of Rsv ...)

2025 JAN 23 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Drug Daily -- Fresh data on RNA Viruses - Respiratory Syncytial Viruses

Article Description

Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory infections in babies across the world. Irrespective of progress in the development of RSV vaccines, effective small molecule drugs are still not available on the market. Based on our previous data we designed and synthesized triazole-linked coumarin-monoterpene hybrids and showed that they are indeed effective in inhibiting the RSV replication. The most effective compounds are active against both RSV serotypes, A and B, with IC in the low micromolar or submicromolar range of concentrations. These are the most active coumarin derivatives found so far. Compound 45 combining 3,7-dimethyloctane and cyclopentane-annealed coumarin fragments has a selectivity index of 160 for serotype A and 1147 for serotype B. According to the results of the time-of-addition experiments, the conjugates are active at the early stages of the virus cycle. Based on biological evaluation and molecular modeling data, RSV F protein is a possible target.

Bibliographic Details

Dmitry O. Tsypyshev; Tatyana M. Khomenko; Konstantin P. Volcho; Nina I. Komarova; Nariman F. Salakhutdinov; Artem M. Klabukov; Daria N. Razgulaeva; Anastasia V. Galochkina; Anna A. Shtro; Sophia S. Borisevich

Royal Society of Chemistry (RSC)

Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics; Chemistry

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know