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Synthesis of 2,2-difunctionalized 2H-azirines via I-mediated annulation of enamines

Organic and Biomolecular Chemistry, ISSN: 1477-0520, Vol: 22, Issue: 11, Page: 2292-2299
2024
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Article Description

Various 2,2-difunctionalized 2H-azirines were synthesized via I-mediated annulation reactions of readily accessible enamines in the presence of nitrogen or non-nitrogen nucleophiles. The features of the present synthesis process also include no use of transition metals, simple operation, mild reaction conditions, a broad substrate scope, and gram-scale synthesis.

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