Syntheses of bottromycin derivatives via Ugi-reactions and Matteson homologations
Organic and Biomolecular Chemistry, ISSN: 1477-0520, Vol: 22, Issue: 44, Page: 8811-8816
2024
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Article Description
New bottromycin derivatives have been prepared using flexible Ugi and Matteson reactions. The Ugi reaction allows the fast and direct assembly of sterically hindered peptide fragments, while the Matteson homologation is excellently suited for the stereoselective synthesis of unusual amino acids like β-methylphenylalanine. Some of the new compounds show excellent activity against Streptococcus pneumoniae.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85206446085&origin=inward; http://dx.doi.org/10.1039/d4ob01373e; http://www.ncbi.nlm.nih.gov/pubmed/39402894; https://xlink.rsc.org/?DOI=D4OB01373E; https://dx.doi.org/10.1039/d4ob01373e; https://pubs.rsc.org/en/content/articlelanding/2024/ob/d4ob01373e
Royal Society of Chemistry (RSC)
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