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Hydrogen-treated CoCrMo alloy: a novel approach to enhance biocompatibility and mitigate inflammation in orthopedic implants

Journal of Materials Chemistry B, ISSN: 2050-7518, Vol: 12, Issue: 32, Page: 7814-7825
2024
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Study Results from National Taipei University of Technology Update Understanding of Orthopedic Implant (Hydrogen-treated Cocrmo Alloy: a Novel Approach To Enhance Biocompatibility and Mitigate Inflammation In Orthopedic Implants)

2024 JUL 16 (NewsRx) -- By a News Reporter-Staff News Editor at Taiwan Daily Report -- A new study on Surgical Technology - Orthopedic Implant

Article Description

In recent decades, orthopedic implants have been widely used as materials to replace human bone tissue functions. Among these, metal implants play a crucial role. Metals with better chemical stability, such as stainless steel, titanium alloys, and cobalt-chromium-molybdenum (CoCrMo) alloy, are commonly used for long-term applications. However, good chemical stability can result in poor tissue integration between the tissue and the implant, leading to potential inflammation risks. This study creates hydrogenated CoCrMo (H-CoCrMo) surfaces, which have shown promise as anti-inflammatory orthopedic implants. Using the electrochemical cathodic hydrogen-charging method, the surface of the CoCrMo alloy was hydrogenated, resulting in improved biocompatibility, reduced free radicals, and an anti-inflammatory response. Hydrogen diffusion to a depth of approximately 106 ± 27 nm on the surface facilitated these effects. This hydrogen-rich surface demonstrated a reduction of 85.2% in free radicals, enhanced hydrophilicity as evidenced by a decrease in a contact angle from 83.5 ± 1.9° to 52.4 ± 2.2°, and an increase of 11.4% in hydroxyapatite deposition surface coverage. The cell study results revealed a suppression of osteosarcoma cell activity to 50.8 ± 2.9%. Finally, the in vivo test suggested the promotion of new bone formation and a reduced inflammatory response. These findings suggest that electrochemical hydrogen charging can effectively modify CoCrMo surfaces, offering a potential solution for improving orthopedic implant outcomes through anti-inflammatory mechanisms.

Bibliographic Details

Lin, Yu-Chien; Hu, Chih-Chien; Liu, Wai-Ching; Dhawan, Udesh; Chen, Yu-Chieh; Lee, Yueh-Lien; Yen, Hung-Wei; Kuo, Yi-Jie; Chung, Ren-Jei

Royal Society of Chemistry (RSC)

Chemistry; Engineering; Materials Science

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