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A novel bivalent single-chain variable fragment (scFV) inhibits the action of tumour necrosis factor α

Biotechnology and Applied Biochemistry, ISSN: 0885-4513, Vol: 50, Issue: 4, Page: 173-179
2008
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Article Description

Suppression of TNFα (tumour necrosis factor α) activity is widely considered to be among the most efficient treatments available for chronic inflammatory diseases. Here, a bivalent scFv (single-chain variable fragment) fragment, named TNF-BAb, was engineered by fusing two anti-TNFα scFV fragments in tandem via a long and flexible linking peptide derived from human serum albumin and produced in functional form from Escherichia coli inclusion bodies. The bioactivity assays demonstrated that TNF-BAb gained enormously in avidity and showed a much stronger ability to inhibit the biological action of TNFα, indicating that TNF-BAb may become a good candidate for anti-TNFα therapy. © 2008 Portland Press Ltd.

Bibliographic Details

Liu, Mengyuan; Wang, Xiangbin; Yin, Changcheng; Zhang, Zhong; Lin, Qing; Zhen, Yongsu; Huang, Hualiang

Wiley

Biochemistry, Genetics and Molecular Biology; Chemical Engineering; Engineering; Immunology and Microbiology; Pharmacology, Toxicology and Pharmaceutics

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