Leukocyte telomere length is associated with iron overload in male adults with hereditary hemochromatosis
Bioscience Reports, ISSN: 1573-4935, Vol: 40, Issue: 10
2020
- 3Citations
- 26Captures
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Metrics Details
- Citations3
- Citation Indexes3
- CrossRef1
- Captures26
- Readers26
- 26
Article Description
Background: Hereditary hemochromatosis (HH) is a primary iron overload (IO) condition. Absolute telomere length (ATL) is a marker of cellular aging and DNA damage associated with chronic diseases and mortality. Aim: To evaluate the relationship between ATL and IO in patients with HH. Methods: Cross-sectional study including 25 patients with HH: 8 with IO and 17 without IO (ferritin < 300 ng/ml) and 25 healthy controls. Inclusion criteria were: Age > 18 years, male sex and HH diagnosis. Patients with diabetes or other endocrine and autoimmune diseases were excluded. ATL was measured by real-time PCR. Results: HH patients with IO were older (P<0.001) and showed higher ferritin concentration (P<0.001). Patients with HH, disregarding the iron status, showed higher glucose and body mass index (BMI) than controls (both P<0.01). ATL was shorter in patients with IO than controls [with IO: 8 (6-14), without IO: 13 (9-20), and controls: 19 (15-25) kilobase pairs, P<0.01]; with a linear trend within groups (P for trend <0.01). Differences in ATL remained statistically significant after adjusting by age, BMI and glucose (P<0.05). Discussion: Patients with IO featured shorter ATL while patients without IO showed only mild alterations vs. controls. Screening for IO is encouraged to prevent iron-associated cellular damage and early telomere attrition.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85094684038&origin=inward; http://dx.doi.org/10.1042/bsr20201916; http://www.ncbi.nlm.nih.gov/pubmed/33026063; https://portlandpress.com/bioscirep/article/40/10/BSR20201916/226596/Leukocyte-telomere-length-is-associated-with-iron; https://dx.doi.org/10.1042/bsr20201916
Portland Press Ltd.
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